Every year in the U.S., more than 65,000 patients are diagnosed with renal cell carcinoma (RCC), the most common type of kidney cancer. Between 15 to 25%, or one in five patients, will be diagnosed when their cancer has spread beyond the kidney to other organs. This is commonly referred to as Stage 4 or metastatic kidney cancer.

Best Available Care

Most patients diagnosed with advanced kidney cancer will have surgery to remove the kidney (this surgery is called a nephrectomy) or to remove the tumor alone. This standard surgery is generally performed by a specially-trained urologist or urologic oncologist. After surgery, the patient is usually referred to an oncologist to begin treatment with one of the many approved targeted drug therapies.

Advanced kidney cancer is usually resistant to chemotherapy, radiation and hormonal therapies. Targeted drug therapy is the best available treatment option for most patients.


Kidney cancer can be difficult to detect, as symptoms can often go unnoticed by the patient. Most commonly, patients may experience:

  • Blood in the urine
  • Lower back pain
  • Growth in the stomach region
  • Unexplained weight loss

Risk Factors include:

  • Older in age
  • Being male
  • Smoking
  • Obesity
  • High blood pressure
  • Hereditary (in some cases)